This course investigates the application of physical chemical principles to problems in the pharmaceutical sciences. Physical and theoretical foundations are discussed and applied and problem solving is emphasized. The prerequisites for this course are general and organic chemistry some calculus.
Text:
A. Martin, et al, Physical Pharmacy, 4th Edition, Lea & Febiger, 1993, or 5th edition, Lippincott Williams & Wilkins, Baltimore, MD 2006.
Objectives:
- Understand the concept of primary units (mass, length, time, electric charge, temperature) and use unit analysis to express all relevant physical quantities in terms of these units.
- Understand basic thermodynamics of equilibrium constants, chemical potential and heats of reaction, phase change, etc.
- Calculate properties for non-electroytic and electrolytic solutions.
- Apply methods of complex equilibria to calculate pH’s and prepare buffers.
- Understand basic chemical kinetic mechanisms and interpret experimental data
- Understand saturable kinetics and apply the model to enzyme kinetics, protein binding, etc.
- Calculate steady state diffusion profiles and interpret experimental data to determine diffusion and permeability coefficients. Design diffusion experiments.
- Understand and apply the Noyes-Whitney and Hixson-Crowell dissolution models.
- Understand properties of interfaces and adsorption processes.
- Be familiar with colloids and coarse dispersions and their preparation (if time permits).
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